Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers.Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1.Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2
Low Heat Input CMT Welding: A Study on Microstructure, Strength, and Corrosion Behavior in Dissimilar Weldments
The low arc heat input welding process can reduce the amount of heat energy required to join the weld metals to produce the desired structures resulted in lower heat-affected zone width, good penetration depth and proper bead geometry formation.In this research, the cold metal transfer welding process was utilized Measuring Cup Sets to join the dis
Factor structure and reliability of the symptom measurement of post-stroke depression in the rehabilitation stage
Abstract Background The incidence of Post Stroke Depression (PSD) in the Rehabilitation Stage is high, which can bring serious physical and psychological disorders to patients.However, there is still a lack of targeted tools for screening VIRAFECT PSD in the rehabilitation stage.Therefore, the aim of this study was to evaluate the factor structure